Sphingoid Base Is Required for Translation Initiation during Heat Stress in Saccharomyces cerevisiae□D
نویسندگان
چکیده
§Department of Biochemistry, University of Geneva, CH-1211 Geneva 4, Switzerland; *Department of Biochemistry, Biozentrum of the University of Basel, CH-4056 Basel, Switzerland; †Department of Microbiology and Molecular Medicine, CMU, University of Geneva, CH-1211 Geneva 4, Switzerland; and ‡Graduate School of Biosphere Science, Faculty of Applied Biological Science, Hiroshima University, Higashi-Hiroshima 739-8528, Japan
منابع مشابه
Sphingoid base is required for translation initiation during heat stress in Saccharomyces cerevisiae.
Sphingolipids are required for many cellular functions including response to heat shock. We analyzed the yeast lcb1-100 mutant, which is conditionally impaired in the first step of sphingolipid biosynthesis and shows a strong decrease in heat shock protein synthesis and viability. Transcription and nuclear export of heat shock protein mRNAs is not affected. However, lcb1-100 cells exhibited a s...
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